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Updated: Jun 1, 2025

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HMG CoA 减少酶 (HMGCR) 缺乏对骨肌肉发育的影响

Mekala Gunasekaran1, Hannah R Littel1, Natalya M Wells1

  • 1Greg Marzolf Jr. Muscular Dystrophy Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.

The FEBS journal
|January 17, 2025
PubMed
概括

致病性HMGCR变种通过损害骨肌肉发育,导致四肢腰带肌肉发育不良. HMGCR 缺乏影响肌细胞增殖,亡和融合,这表明在与 HMGCR 相关的肌肉疾病中存在共同的机制.

关键词:
在HMGCR中,HMGCR是最重要的.肌肉发育不良 肌肉发育不良 肌肉发育不良骨髓质细胞细胞质细胞质细胞质细胞质细胞质细胞质细胞质.这是骨肌肉的骨架肌肉.类药物 肌肉病变

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