在当代儿科样本中,压力的骨和脂肪表现
Lexi O'Donnell1,2,3, Louise Corron4, Ethan C Hill5
1College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
American journal of biological anthropology
|January 17, 2025
概括
早期的生活压力会影响骨发育和内分泌功能. 研究结果将多孔的头骨病变和较小的脊椎通道与脂肪组织分布的改变联系起来,这表明压力会影响骨健康和新陈代谢.
科学领域:
- 儿科骨生物学 儿科骨生物学
- 内分泌学 在内分泌学.
- 健康和疾病的发育起源.
背景情况:
- 早期的生活压力会破坏内分泌和代谢系统,影响骨发育.
- 骨的指标,如状高静止症 (PH) 和状轨道 (CO) 可能反映生理压力.
- 与脂肪组织一起研究压力标志物,为儿童健康提供了洞察力.
研究的目的:
- 评估早期生活压力对儿童脂肪和骨组织的影响.
- 检查骨应力指标 (PH/CO),骨矿物质密度 (BMD),脊椎神经通道 (VNC) 尺寸和脂肪组织分布之间的关系.
- 了解孕期和儿童时期的压力因素如何影响骨和内分泌系统的发育.
主要方法:
- 一个儿科尸检样本的分析 (N=702,年龄为0.5-20.9岁).
- 数据收集包括腹部,心脏和肝脏的内脏脂肪组织 (VAT),CO/PH存在,第五腰部VNC大小和BMD.
- 统计检查骨标记,VNC大小和脂肪组织分布之间的关联.
主要成果:
- 脂肪组织的分布和位置显示出与CO/PH,BMD和VNC大小的差异关联.
- 患有CO/PH的个体具有较小的VNC大小和较高的肝脂肪度.
- 增加的增值税和更小的VNC规模与PH和低BMD有关,独立于BMI类别.
结论:
- 证据支持骨压力标志物 (CO/PH,减少VNC大小,低BMD) 和内分泌功能之间的复杂联系.
- 增值税分配和VNC大小似乎部分是由通过HPA轴变化的妊娠压力因素塑造的.
- 孕期压力可能会影响在儿童时期的压力暴露期间多孔 lesions的表达.
相关概念视频
Introduction to Stress and Lifestyle
74
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
74
Psychological Responses to Stress
42
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
42
Physiological Foundation of Stress
43
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
43
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Hypothalamic-Pituitary Axis
59.2K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.2K
Psychoneuroimmunology: Diabetes and Cancer
22
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
22


