估计与中国农村老年人口的认知表型相关的脉冲波速度:一个队列研究
Jiahui Li1, Yifei Ren2, Lidan Wang2
1Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|January 17, 2025
概括
估计较高的脉冲波速度 (ePWV) 与中国老年人的痴呆风险增加和认知衰退速度更快有关. 这一发现凸显了ePWV作为认知衰老和神经退行性疾病的潜在指标.
科学领域:
- 老年学是一门学科.
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
背景情况:
- 通过估计的脉冲波速度 (ePWV) 测量的血管硬是心血管衰老的标志物.
- 认知能力下降和痴呆症是老龄化人口的重大公共卫生问题.
研究的目的:
- 为了研究ePWV与中国农村老年人队列的认知功能之间的纵向关系.
- 为了确定ePWV是否预测发展痴呆症和阿尔茨海默病 (AD) 的风险.
主要方法:
- 一项针对1857名没有痴呆症的成年人 (≥60岁) 的基于人口的研究,随访时间为4年.
- 根据年龄和平均血压计算的ePWV;通过MMSE和神经心理测试评估认知功能.
- 统计分析包括考克斯模型,线性回归和受限立方线.
主要成果:
- 每增加1m/s的ePWV与痴呆的风险增加1.51倍和AD的风险增加1.58倍相关.
- 较高的ePWV与迷你精神状态考试 (MMSE) 成绩显著下降有关 (-0.36分).
- 在基线ePWV和随访时的认知表现之间发现了非线性关联.
结论:
- 升高的ePWV是老年人痴呆症,AD和加速认知衰退的重要危险因素.
- 增加的ePWV可能表明老年人对认知恶化和神经退行症的倾向.
- ePWV作为一种潜在的生物标志物,用于监测老年人群的认知健康.
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