吸食大麻会引起人类支气管上皮细胞中炎症,氧化应激和癌症途径所涉及的转录和代谢变化
Maddison T Arlen1,2,3, Stephanie J Patterson1,3, Michelle K Page4
1Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
概括
大麻蒸汽喷雾剂含有有毒物质,包括致癌物质,类似于大麻烟雾. 这两种方法都会诱导细胞应激和炎症,挑战电子烟作为更安全的替代品的看法,并突出潜在的肺部健康风险.
科学领域:
- 肺部病理学 肺部病理学
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 大麻的使用正在从吸烟转向电子烟,电子烟被认为更安全.
- 这一转变的部分原因是年轻人的吸引力和感知到的减少伤害.
- 关于大麻电子烟与吸烟对健康的影响的研究有限.
研究的目的:
- 为了比较大麻烟雾提取物 (CaSE) 和大麻蒸汽提取物 (CaVE) 的化学成分和生物活性.
- 研究CaSE和CaVE对人类支气管上皮细胞的影响.
- 挑战大麻电子烟是吸烟的无风险替代品的观念.
主要方法:
- 使用HPLC和GC/MS对CaSE和CaVE进行化学分析.
- 使用基于BRET的生物传感器评估受体介导活性.
- 通过RNA测序和肺细胞的向代谢学来进行转录概况.
主要成果:
- 大麻蒸汽喷雾剂含有比烟雾少的有毒物质,但这两种提取物都含有致癌物,致癌物和呼吸道毒物.
- 无论是CaSE还是CaVE都诱导了与炎症,癌症和细胞压力相关的类似的转录反应.
- 代谢分析显示肺上皮细胞修复和功能受损,表观遗传变化 (5hmC) 表明癌症风险增加.
结论:
- 大麻蒸汽气溶并非没有风险,并且含有有害的有毒物质.
- 蒸汽和吸食大麻都会在肺部引起类似的不良细胞反应.
- 进一步的研究对于公共卫生政策和消费者对大麻吸入风险的认识至关重要.
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