反流过敏症真的是一种功能性胃肠道疾病吗? 一个回顾性横截面研究
Yanping Wu1, Siyu Liao1, Tianyao Qu1
1Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
PloS one
|January 17, 2025
概括
反流过敏症 (RH) 显示出明显的病理变化,与其他功能性食道疾病不同. 这表明RH可能不符合目前的功能性胃肠道疾病分类.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 功能性胃肠道疾病 功能性胃肠道疾病
背景情况:
- 逆流过敏症 (RH) 是一个新的功能性食道疾病根据罗马四号标准.
- 这项研究比较了RH,非侵蚀性反流性疾病 (NERD) 和功能性胃灼热 (FH) 的临床特征.
- 所有条件都呈现为内镜负性胃灼热.
研究的目的:
- 为了比较RH,NERD和FH的临床特征.
- 调查诊断标记物的潜在差异.
- 评估RH在功能性胃肠道疾病中的分类.
主要方法:
- 对24小时MII-pH和HRM跟踪的回顾性分析.
- 包括2017年1月1日至2021年3月10日期间被诊断患有胃烧的118名患者.
- 盲目的分析比较了NERD,RH和FH组中的临床特征.
主要成果:
- 在群体之间,人口统计学 (年龄,性别,BMI,吸烟,酒精) 没有显著差异.
- 在NERD和RH中比在FH中更为普遍的椎 (P < 0.05).
- 与FH相比,在NERD和RH中较低的远端MNBI和PSPW指数 (P <0.05),远端MNBI显示出诊断潜力.
结论:
- 反流过敏症表现出明显的病理变化,与其他功能性胃肠道疾病不同.
- 目前将RH归类为功能性胃肠道疾病,可能需要重新评估.
- 远端MNBI显示出作为诊断标记物来区分这些疾病的前景.
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