揭示城市大气颗粒物中新出现的多环芳香化合物
Jia-Yong Lao1, Tingyu Li2, Le Jing1
1State Key Laboratory of Marine Pollution and Department of Chemistry, City University of Hong Kong, Hong Kong 999077, China.
Environment international
|January 17, 2025
概括
对大气中的多环芳香化合物 (PACs) 的健康风险进行了鉴定和评估. 多环芳 (PAH) 构成最高风险,突出需要更好的暴露减轻策略.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 风险评估 风险评估
背景情况:
- 大气中的多环芳香化合物 (PAC) 广泛存在,但人们对其了解甚少,这阻碍了对健康风险的准确评估.
- 许多PAC缺乏足够的毒性数据,这使得对它们对人类健康的影响的评估变得复杂.
研究的目的:
- 通过先进的选方法,在大气颗粒物中识别未知的PAC.
- 评估与各种PAC相关的毒性和健康风险,包括新型类似物.
- 开发一种风险评估模型,用于吸入复杂PAC混合物的风险.
主要方法:
- 使用内部和自主开发的光谱数据库对大气颗粒物的非目标选.
- 吸收,分布,新陈代谢,分泌和毒性 (ADMET) 属性的评估.
- 开发和应用一种新的健康风险评估模型,用于吸入暴露.
主要成果:
- 在室外大气颗粒物中的八个类别中识别了98种PAC类似物.
- PAC度是源特定的,与总共16种优先的多环芳 (PAH) 相关.
- 虚拟查表明新陈代谢和内分泌干扰是潜在的非致癌效应;PAH和氧化PAH显示出更高的不良结果潜力.
结论:
- 多环芳 (PAH) 在已识别的PAC中呈现出最高的致癌和非致癌风险.
- 新兴的PAHs对总体致癌 (47%) 和非致癌 (27%) 风险作出了重大贡献.
- 这些发现有助于更好地了解PACs的有害影响,并为减轻复杂混合物吸入风险的策略提供信息.
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