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尿膀癌微环境中的非编码RNA:诊断,治疗和预后视角

Enas A El Saftawy¹, Basma Emad Aboulhoda², Marwa Ali AbdElkhalek³

¹Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt; Department of Medical Parasitology, Armed Forces College of Medicine, Cairo, Egypt.

Pathology, research and practice

|January 17, 2025

概括

非编码RNAs (ncRNAs) 在尿膀癌 (UBC) 的发展中至关重要. 了解它们的作用为这种常见恶性瘤提供了新的诊断和治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

尿道膀癌 (UBC) 是一种常见的恶性瘤,对标准治疗的临床反应是可变的.
现在,UBC的分子基础正在进行密集的研究,推动着寻找新的诊断和治疗点的研究.

研究的目的:

本综述综合了关于UBC病变发生中的非编码RNA (ncRNA) 的当前知识.
突出ncRNAs在临床环境中的诊断,治疗和预后潜力.

主要方法:

在主要科学数据库 (Google Scholar,PubMed,EKB,Web of Science) 中使用关键字进行了全面的文献搜索.
专注于最近的研究,涉及与UBC相关的各种ncRNA类别.

主要成果:

非编码RNAs (ncRNAs),包括微RNAs (miRNAs) 和长非编码RNAs (lncRNAs),是UBC研究的核心.
其他ncRNAs,如snoRNAs,PIWI相互作用RNAs,线粒体RNAs,圆形RNAs,以及与Schistosoma haematobium相关的ncRNAs也会对UBC的病变产生贡献.

结论:

在瘤微环境 (TME) 中,瘤原和瘤抑制性ncRNAs的平衡和相互作用是UBC进展的关键决定因素.
分析ncRNAs为UBC TME提供了有价值的见解,为改善临床管理铺平了道路.

关键词:

一个圆形的圆形圆形.在 LncRNAs 中.这就是米RNAs.线粒体RNAs是什么没有编码的RNAs.与PIWI相互作用的RNAs.史基斯托索马血组织.这就是SnoRNAs.膀癌是尿道癌症的一种.

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...