在致病性细菌中,β-乳酸胺抗性基因blaTEM-1的全球传播
Adeel Farooq1, Asma Rafique2, Eunyoung Han3
1Research Institute for Basic Sciences (RIBS), Jeju National University, 102 Jejudaehak-ro, Jeju 63243, Republic of Korea.
The Science of the total environment
|January 17, 2025
概括
抗生素耐药性是一个主要的威胁,超过70%的病原体具有耐药性. 这项研究分析了618,853个基因组,重点关注blaTEM-1基因,以了解抵抗模式和传播.
科学领域:
- 基因组学就是基因组学.
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 抗生素耐药性是一个关键的全球健康挑战.
- 超过70%的致病细菌对至少一种抗生素具有抗性.
- 了解抵抗模式和传播是至关重要的.
研究的目的:
- 使用大规模基因组数据集分析抗生素耐药性模式.
- 调查blaTEM-1基因的流行和分布.
- 探索移动遗传元素在抗生素耐药性基因传播中的作用.
主要方法:
- 来自NCBI病原体检测数据库的618,853种致病细菌基因组的分析.
- 专注于β-乳酸胺抗性基因blaTEM-1的研究.
- 鉴定和分析了15个突出的抗生素耐药性基因 (ARG).
- 对遗传背景和移动遗传元素 (MGE) 的检查.
主要成果:
- 在43339个基因组中发现了blaTEM-1基因,分布在8个物种和11个隔离源中.
- 15个关键ARG的流行率,包括对β-乳酸,氨基糖化物和四环素耐药性的ARG.
- 在格拉姆阳性和格拉姆阴性细菌之间观察到明显的耐药性模式.
- blaTEM-1经常与像转子体一样的MGE相关,这表明横向基因转移的潜力.
结论:
- 基因组监测对于了解ARG传播至关重要.
- 移动遗传元素在抗生素耐药性的传播中发挥着重要作用.
- 一个健康的方法对于应对不断升级的抗生素耐药性危机至关重要.
更多相关视频
06:56Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli
Published on: March 24, 2023
5.1K
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
6.3K
相关概念视频
01:33Bacterial Transformation
55.1K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
55.1K
00:57Antibiotic Selection
52.2K
Overview
52.2K
00:46Genomic DNA in Prokaryotes
43.4K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.4K
01:30Bacterial Signaling
31.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
31.5K