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Updated: Jun 1, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
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通过整合批量和scRNA-seq数据来实现细胞类型特定的eQTL优先级的统一框架

Xinyi Yu1, Xianghong Hu2, Xiaomeng Wan2

  • 1Shenzhen Research Institute of Big Data, Shenzhen 518172, China; School of Data Science, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen 518172, China.

American journal of human genetics
|January 17, 2025
PubMed
概括

我们开发了IBSEP,这是一种新方法,集成了大量和单细胞RNA测序数据,以改善细胞类型特定的eQTL (ct-eQTL) 发现. 这种方法增强了对细胞水平上复杂疾病的遗传影响的理解.

关键词:
在GWAS中,GWAS就是GWAS.在eQTLs中使用.表达方式 定量特征 loci loci全基因组关联研究研究.这就是 scRNA-seqq.一个单细胞RNA测序.统计遗传学 统计遗传学

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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