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对海棘聚丰富分数及其脂复合物 (植物体) 制剂的抗炎活性,稳定性,生物利用性和毒性研究

Dattatraya Dinkar Gore¹, Nidhi Mishra², Dinesh Kumar³

¹Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, 160062, Punjab, India.

International journal of biological macromolecules

|January 17, 2025

概括

一种新型的脂复合物 (IPHRFPPEF-PC) 显著提高了标准化聚丰富分量的生物可用性和抗炎作用 (IPHRFPPEF). 这种安全有效的配方在治疗炎症病症方面表现有前途.

科学领域:

药理学药理学是指药理学的学科.
自然产品化学自然产品化学
药物运输药物运输药物运输

背景情况:

聚醇具有抗炎性质,但通常患有口服生物可用性差.
开发有效的输送系统对于增强天然化合物的治疗潜力至关重要.

研究的目的:

为了制备一个脂复合物 (IPHRFPPEF-PC) 的标准化聚丰富分数 (IPHRFPPEF).
评估IPHRFPPEF-PC.PC的口服生物可用性,稳定性,毒性和体内抗炎活性.

主要方法:

使用树脂柱染色学和HPLC和NMR分析的IPHRFPPEF制剂.
通过溶剂蒸发形成脂复合体.
在Sprague Dawley大鼠中进行的药理动力学研究和急性/重复剂量毒性评估.

主要成果:

在IPHRFPPEF-PC中,主要多醇 (isorhamnetin,kaempferol,quercetin) 的血度显著增加.
急性口服毒性显示LD50>5000毫克/公斤 (GHS类别5),重复剂量研究证实了安全性.
IPHRFPPEF-PC在体内表现出强大的抗炎作用和增强的药理动力学特性.

结论:

脂复合物配方 (IPHRFPPEF-PC) 有效地提高了多的口服生物可用性和治疗疗效.
IPHRFPPEF-PC代表了一种安全而有前途的方法来管理炎症状况.

关键词:

和毒性以及毒性.抗炎药物抗炎药物抗炎药物生物可用性生物可用性脂复合体是一种脂复合体.聚醇丰富分离物聚醇丰富分离物海的棘是一种棘.

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