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Updated: Jun 1, 2025

Test Samples for Optimizing STORM Super-Resolution Microscopy
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超分辨率显微镜作为一种药物发现工具.

Lauren Toms1, Lorna FitzPatrick1, Philip Auckland1

  • 1Medicines Discovery Catapult, Block 35, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4ZF, United Kingdom.

SLAS discovery : advancing life sciences R & D
|January 17, 2025
PubMed
概括

超分辨率显微镜突破了衍射极限,通过揭示分子细节,彻底改变了细胞生物学. 这种先进的成像现在对于理解人类疾病和加速药物发现至关重要.

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Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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