在香港发生了急性Sophora类中毒
Tsz Kit Chow1, Rex Pui Kin Lam1, Chi Keung Chan2
1Department of Emergency Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Postal address: G/F, Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Pokfulam, Hong Kong, China.
概括
急性Sophora类中毒通常与过量服用Sophora flavescens有关,通常会引起轻微症状,如头和吐. 在香港的病例中没有观察到严重的不良影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 草药是一种草药.
背景情况:
- 索波拉类化合物 (马特林,氧马特林,索波里丁) 是来自中国传统医药植物的奇诺利齐丁.
- 在中国大陆以外的急性Sophora化物中毒报告很少.
- 这项研究解决了香港中毒病例数据的缺乏问题.
研究的目的:
- 描述香港急性Sophora化物中毒的临床表现,管理和结果.
- 确定与中毒有关的主要来源和常见症状.
- 评估严重不良事件的发生,如肝毒性和皮肤反应.
主要方法:
- 报到香港中毒控制中心的中毒病例的回顾性研究 (2008年7月至2021年6月).
- 对患者人口统计,临床数据,管理策略和结果的分析.
- 实验室证实了Sophora类化合物暴露的情况.
主要成果:
- 分析了83个病例;Sophora flavescens是主要来源 (77.1%),过量剂量很常见 (39.0%).
- 大多数患者 (90.4%) 经历了轻微的副作用,主要是头 (83.1%),吐 (72.3%) 和心 (32.5%).
- 没有观察到急性肝/损伤或皮肤反应;治疗是支持性的,不需要去污染或器官支持.
结论:
- 过多的Sophora flavescens摄入是急性Sophora类中毒的常见原因,通常有轻微的症状.
- 在其他研究中注意到的肝毒性和皮肤反应在这个队列中没有观察到.
- 需要进一步的研究,以澄清由于配方和研究变化的真实世界皮肤反应和肝毒性风险.
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