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Updated: Jun 1, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
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发现含有的衍生品作为有力且可口服生物利用的GLP-1R激活剂

Xuetao Chen1,2, Shicheng Xu1,2, Shuang Yang1,2

  • 1Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Journal of medicinal chemistry
|January 17, 2025
PubMed
概括

新的含化合物显示出治疗2型糖尿病和肥胖的前景. 化合物21是一种口服可用的葡萄糖类-1受体 (GLP-1R) 激动剂,有效降低了小鼠的血糖和食物摄入量,没有观察到任何不良影响.

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