斜视和异度双眼对人类视觉皮层中等尺度功能组织的不同影响
Shahin Nasr1,2, Jan Skerswetat3, Eric D Gaier4,5,6
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129 shahin.nasr@mgh.harvard.edu.
概括
无视度和斜视眼对视野皮层组织有独特的影响. 高分辨率的fMRI揭示了明显的眼睛主导反应,显示偏会影响V1深度相关性,而异度偏差会改变视觉区域的响应模式.
科学领域:
- 神经科学是一个神经科学.
- 视觉神经科学是一种神经科学.
- 功能神经成像 功能神经成像
背景情况:
- 眼是一种发育性视觉障碍,在关键时期因异常视觉体验而产生.
- 不同度差 (不平等的折射误差) 和斜视 (眼睛的 misalignment) 是眼的常见原因.
- 以前的研究从动物模型和间接的人类研究中推断出对视觉皮层组织的影响.
研究的目的:
- 为了区分异观视差和斜视眼对人类视觉皮层眼睛主导 (OD) 反应的功能影响.
- 调查这些条件如何改变视觉区域V1-V4.4的中等尺度功能组织.
主要方法:
- 使用高分辨率功能磁共振成像 (fMRI) 测量左眼和右眼刺激之间的大脑反应差异.
- 参与者包括患有眼 (异度和眼) 的人和健康的对照人.
- 在视觉区域V1-V4.4中分析了眼睛主导 (OD) 反应模式,偏差,双眼反应和V1深度相关性.
主要成果:
- 与对照组相比,眼患者的参与者表现出更大,融合的OD响应斑块延伸到更高的视觉区域.
- 不论是异度眼和偏眼,都导致了V1-V4.4的OD反应升高.
- 无视度表现出更大的V1区域的增加有利于同眼刺激和双眼响应幅度的更大的差异.
- 然而,,在V1.1的表面和深层之间显示了OD反应的相关性增加.
结论:
- 这项研究提供了第一个直接的功能证据,证明了异度不均和对人类视觉系统中等尺度组织的明显影响.
- 这些发现突出显示,不同的基因因素导致视觉皮层功能架构的独特变化.
- 结果扩展了对野视的理解,超越了动物模型,强调不同类型视力障碍的不同神经基质.
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