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Sara Elyas¹, Pedro Barata², Ulka Vaishampayan³

¹Lyman Briggs College, Michigan State University, East Lansing, MI, USA.

European urology focus

|January 17, 2025

概括

肠道微生物群对癌症治疗结果产生影响,特别是对于接受免疫检查点抑制剂 (ICI) 的细胞癌 (RCC) 患者. 用益生菌或益生菌调节微生物组可能会改善对这些疗法的反应.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
免疫治疗是一种免疫疗法.

背景情况:

免疫检查点抑制剂 (ICI) 改善了转移性细胞癌 (RCC) 的存活率.
肠道微生物组的组成显著影响ICI治疗的疗效.
微生物组的破坏,例如来自抗生素,与较差的治疗结果有关.

研究的目的:

在癌症治疗中探索针对微生物组的干预措施,以克服对免疫检查点抑制剂 (ICI) 的耐药性.
审查特定微生物菌株和益生菌在增强抗癌免疫反应中的作用.
讨论益生菌,益生菌和便微生物群移植在改善ICI疗效方面的潜力.

主要方法:

关于微生物组研究及其与癌症治疗的联系的当前文献的综述.
对研究特定细菌菌株 (如Akkermansia muciniphila,Clostridium butyricum) 及其影响的研究进行分析.
探索益生菌干预措施,如用于改变肠道菌群的胰岛素凝.

主要成果:

某些肠道微生物菌株与ICI治疗的患者的增强免疫反应和改善无进展生存率有关.
益生菌干预显示了调节肠道微生物群的潜力,以克服对免疫治疗的抵抗力.
针对微生物组的治疗方法,包括前/益生菌和便微生物群移植,有望提高ICI的疗效.

结论:

针对微生物组的干预措施有望改善ICI治疗的晚期RCC患者的治疗结果.
进一步的未来随机试验对于标准化临床应用和优化这些治疗方法至关重要.
目前的肠调节疗法在临床试验之外不建议使用,目前正在进行的研究如BIOFRONT试验正在调查其作用.

关键词:

免疫疗法是一种免疫疗法.脏癌症是什么? 脏癌症是什么微生物组是一个微生物组.益生菌益生菌是一种益生菌.

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