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携带WNT10A突变,具有不同分子状态和表型的患者的牙科植入物康复:回顾性队列研究

Jiaqi Dou^1,2,3,4,5,6, Qinggang Dai^1,2,3,4,5,6, Xinbo Yu^1,2,3,4,5,6

¹Second Dental Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Clinical oral implants research

|January 17, 2025

概括

对于WNT10A突变导致牙衰老的患者来说,牙植入物是可以预测的. 在植入物治疗之前,遗传诊断对于在严重病例中管理骨质损失增加至关重要.

科学领域:

遗传学是一个遗传学.
口腔和牙面部外科手术
牙科植入物学牙科植入物学

背景情况:

已知WNT10A突变是导致牙产生的一种原因.
在这个人群中评估长期的牙科植入物结果对于治疗规划至关重要.

研究的目的:

为了评估牙科植入物在WNT10A突变患者的临床成功.
为了将结果与分子状态 (同卵性,异卵性,复合异卵性) 和表型严重程度相关联.
分析长期植入物存活率和边际骨损失 (MBL).

主要方法:

整体外体序列测序 (WES) 确定了患有牙生殖和WNT10A突变的患者.
一组27名接受牙科植入物治疗的患者被追溯分析.
在长期随访中评估了植入物存活率,MBL和患者报告的结果 (满意度,OHIP-C49).

主要成果:

相比于异构体和复合异构体,同类异构体的牙缺失明显多.
整体植入失败率在受试者层面为14.8%,在植入层面为4.4%.
五年累计存活率为85.2% (受试者) 和95.6% (植入物).
在同卵性动物中观察到更高的MBL,需要骨增强的病例,前部区域和全桥.
患者满意度和OHIP-C49分数均为良好.

结论:

牙科植入物康复是WNT10A突变个体的可预测治疗方法.
在同卵性动物和需要骨增强的病例中增加的MBL强调了遗传评估的重要性.
在植入物治疗前对因WNT10A突变而导致严重牙发育的患者推进行遗传诊断.

关键词:

这是WNT10A.骨增强骨增强是一种骨增强.牙植入物是指牙植入物.牙生长过程中的牙.整个exome测序的测序

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