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对离子甲氨酸的聚合控制,使激发波长具有选择性的NIR-II光成像引导的光动力学疗法

Yibin Li¹, Fei Qu¹, Fang Wan¹

¹Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, State Key Laboratory of Materials Processing and Die & Mould Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.

Nature communications

|January 17, 2025

概括

这项研究引入了一种用于增强近红外II (NIR-II) 光成像引导光动力学疗法 (PDT) 的新光敏感剂. 这种新的方法通过优化染料聚合和活性氧物种生成来改善瘤诊断和治疗.

科学领域:

生物医学工程生物医学工程
光动力学疗法光动力学疗法
光成像技术光成像

背景情况:

近红外II (NIR-II) 光成像导向光动力疗法 (PDT) 显示为深层组织瘤治疗的前景.
光敏剂聚合和光和活性氧物种 (ROS) 生产之间的竞争限制了当前的NIR-II PDT性能.

研究的目的:

开发一种离子甲氨酸 (C5T) 光敏剂,用于高性能NIR-II光成像引导的PDT.
为了克服光敏剂聚合的局限性,并优化ROS生成以改善瘤治疗.

主要方法:

合成了一种用乙烯甘醇链修改的三酸 (Pco),作为C5T的对应物.
采用 counterion 工程来抑制染料聚合并增强素- counterion 相互作用.
在总体层面上利用了光和ROS生成的动态调整.

主要成果:

通过优化两性感和增强相互作用,通过优化两性感和增强相互作用,实现了C5T-Pco光敏剂的抑制聚合.
在760nm光照射下证明有效的I型ROS生成.
在808nm激发时观察到高效的NIR-II光发射.
在雌性小鼠中成功执行了激发波长选择性NIR-II光成像引导的PDT用于瘤诊断和治疗.

结论:

开发的C5T-Pco光敏感剂有效地解决了NIR-II光成像引导PDT中的聚合问题.
这种方法可以实现光和ROS生成的动态调整,从而改善诊断和治疗结果.
激发波长选择性的NIR-II光成像引导的PDT显示了精确瘤治疗的巨大潜力.

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