NKAPL促进了转录暂停释放,并在半变异退出过程中将延长桥接到启动

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Updated: Jun 1, 2025

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events

Published on: May 13, 2019

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Zhenlong Kang1, Chen Xu1, Shuai Lu1,2,3

  • 1State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.

Nature communications
|January 17, 2025
PubMed
概括

NKAPL蛋白对男性生育能力至关重要,通过促进转录延长和协调转录启动来调节变期间的基因表达. 它的枯竭导致不孕不育,并阻碍了生育过程的退出.

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Transcription Elongation Factors02:35

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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
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