过敏性鼻炎治疗对喘控制的影响:系统性审查
Ellen Tameeris1, Arthur M Bohnen2, Patrick J E Bindels2
1Erasmus MC, Department of General Practice, Rotterdam, The Netherlands. e.tameeris@erasmusmc.nl.
NPJ primary care respiratory medicine
|January 17, 2025
概括
用抗胺剂 (AH) 和皮质类固醇治疗过敏性鼻炎 (AR) 可以改善喘结果,特别是生活质量和客观喘结果 (OAO). 胰岛素受体对抗剂 (LRA) 没有显著改善喘.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床免疫学临床免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘和过敏性鼻炎 (AR) 经常同时存在,影响呼吸系统健康.
- 有效的AR症状控制对于管理患有这两种疾病的患者的喘至关重要.
研究的目的:
- 系统地审查抗AR药物对喘结果的有效性.
- 评估抗组胺剂 (AH),皮质类固醇和白血受体对抗剂 (LRAs) 在患有并发性喘和AR的患者中.
主要方法:
- 从Embase,Medline和Cochrane数据库中对随机对照试验 (RCT) 进行系统审查,直到2024年10月.
- 包括评估AH,皮质类固醇或LRA与安慰剂或常规喘治疗的RCT.
- 测量结果包括客观喘结果 (OAO) 和主观喘结果 (SAO),以及生活质量 (QoL).
主要成果:
- 包括33个RCT,其种群范围从完全儿科到部分儿科.
- 在SAO中没有观察到临床相关的改善.
- 在 QoL (五项研究) 和 OAO (四项研究) 中发现了显著的,临床相关的改善.
- LRAs没有显著改善;皮质类固醇的表现优于LRAs.
- 喘患者和皮质类固醇对喘结果产生了积极影响,而喘患者表现出比其他群体更大的影响.
结论:
- 抗过敏药物,特别是AH和皮质类固醇,对具有同时存在AR的患者的喘结果产生积极影响.
- 改善在QoL和OAO中最明显,而SAO显示出有限的临床相关性.
- 在这种患者群体中,LRA似乎无效改善喘结果.
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