通过基于半固体挤出的3D打印进行个性化医疗:双药加载的口香糖,以提高患者合规性
Aditi Holkunde1, Indrajeet Karnik1, Prateek Uttreja1
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.
Pharmaceutical research
|January 17, 2025
概括
3D打印技术被用来创建个性化的伊索尼亚齐德-皮里多克辛用于结核病治疗. 与传统的药丸相比,这些片提供了更好的口感和粘附性.
科学领域:
- 制药技术 制药技术 制药技术
- 3D打印应用 3D打印应用
- 药物输送系统 药物输送系统
背景情况:
- 传统的结核病治疗面临的挑战是药丸负担和食用性.
- 个性化医疗方法对于改善患者的坚持和治疗结果至关重要.
- 3D打印为定制药物剂量形式提供了创新的解决方案.
研究的目的:
- 开发和描述使用半固体挤出 (SSE) 3D打印的双药物伊索尼亚-皮里多克辛.
- 为了使儿童和老年患者的个性化剂量.
- 为了应对结核病治疗中药丸负担和可口性的挑战.
主要方法:
- 使用凝,卡拉基南和西醇制造的.
- 使用BIO X 3D打印机进行半固体挤出 (SSE).
- 评估风湿性质,体外药物释放和稳定性的评估.
- 用FT-IR光谱进行药物辅助剂相互作用分析.
主要成果:
- 优化的F3配方 (900毫克伊索尼亚,30毫克皮里多克素) 显示出成功的印刷性和结构完整性.
- 超过80%的药物在30分钟内释放,具有理想的印制rheological属性.
- 适合儿科遵守的纹理特性和在冷藏下持续30天的药物含量/释放.
结论:
- 通过SSE 3D打印,可以制造个性化的伊索尼亚齐德-皮里多克辛,用于结核病治疗.
- 开发的片提供了患者友好的剂量形式,具有出色的可打印性,稳定性和快速释放药物.
- 3D打印的片代表了对传统的口服剂型的有希望的替代方案,以提高患者的坚持.
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