卡纳比和Hydroxypropyl-β-Cyclodextrin用于开发空气化球形可吸入粉末
Bernardo Filipe Santos Gomes1,2, Laure-Anne Bya1, Nathan Koch1
1Laboratory of Pharmaceutical Technology and Biopharmacy, CIRM, University of Liège, 4000, Liège, Belgium.
The AAPS journal
|January 17, 2025
概括
在这项研究中,使用喷雾干燥和环氧德克斯特林开发了一种可吸入的甘二醇粉末. 工程粉末显示有前途的气溶液化行为,有效的肺部药物输送.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 纳米技术在医学中的应用
背景情况:
- 大麻二醇 (CBD) 显示出用于肺部的治疗潜力,包括用于癌症.
- 肺部药物输送在可呼吸分数和产品标准化方面面临挑战.
- 干粉吸入器 (DPI) 提供稳定性和易用性,颗粒工程显示出有前途.
研究的目的:
- 通过喷雾干燥使用颗粒工程开发可吸入的大麻 (CBD) 粉末.
- 调查基基-β-环氧的使用,作为一种可溶性增强剂,用于水溶性较差的CBD.
- 评估工程化CBD粉末的气溶液化特性和深肺沉积潜力.
主要方法:
- 使用喷雾干燥方法,使用氧-β-环氧和乙醇制造CBD粉末.
- 用电子显微镜和粒子大小分析来描述粉末形态和大小.
- 细颗粒物分量 (FPF) 被确定以评估深肺沉积的气溶性能.
主要成果:
- 产生了一致的空气化球形CBD粉末,尺寸适合深肺沉积 (约2微米).
- 工程粉末呈现出高微粒分数 (>60%),这归因于它们独特的表面形态.
- 开发的粉末显示出快速溶解,这对治疗疗效至关重要.
结论:
- 通过喷雾干燥的粒子工程成功地创造了一种可吸入的CBD粉末,具有有利的气溶特性.
- 这种无载体配方方法对水溶性较差的药物有效,为未来的体内研究铺平了道路.
- 该研究强调了循环德素辅助喷雾干燥在开发先进的肺药物递送系统方面的潜力.
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