对数字双胞胎用于精准医学的验证,验证和不确定性量化的调查和观点
Kaan Sel1, Andrea Hawkins-Daarud2, Anirban Chaudhuri3
1Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, MA, USA.
NPJ digital medicine
|January 17, 2025
概括
数字双胞胎通过模拟患者健康来提供个性化医疗. 验证,验证和不确定性量化 (VVUQ) 对于确保这些数字工具在临床环境中的安全性和有效性至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
- 医疗信息学 医疗信息学
背景情况:
- 精准医学旨在利用个体变化量身定制医疗保健.
- 数字双胞胎模拟患者特定的健康轨迹和干预措施.
- 确保数字双胞胎的可靠性对于临床采用至关重要.
研究的目的:
- 检查验证,验证和不确定性量化 (VVUQ) 在精准医学数字双胞胎中的作用.
- 突出VVUQ对数字生应用程序的安全性和有效性的重要性.
- 在医疗保健中将VVUQ应用于数字双胞胎的挑战和机遇.
主要方法:
- 对应用到数字双胞胎技术的VVUQ原则的审查.
- 心脏病学和瘤学的案例研究示例.
- 对个性化试验方法和验证指标的需求分析.
主要成果:
- VVUQ对于建立数字双胞胎的可信度至关重要.
- 具体的VVUQ挑战包括开发患者特定的验证指标.
- 在标准化VVUQ流程中存在机会,以实现更广泛的整合.
结论:
- 数字双胞胎对个性化医疗具有重大前景.
- 强大的VVUQ框架对于数字双胞胎的安全有效的临床整合是不可或缺的.
- 标准化的VVUQ方法将加速在医疗保健中采用数字双胞胎.
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