代谢综合征与癌症诊断后预期寿命之间的影响:加泰罗尼亚队列研究
Tomàs López-Jiménez1,2, Oleguer Plana-Ripoll3,4, Talita Duarte-Salles1,5
1Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de Les Corts Catalanes, 587 Àtic, 08007, Barcelona, Spain.
BMC public health
|January 17, 2025
概括
具有较少代谢综合征成分的癌症患者有更长的剩余寿命 (RLE). 解决代谢综合征可以改善癌症幸存者的生存率.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 剩余预期寿命 (RLE) 是癌症幸存者的关键指标.
- 代谢综合征 (MS) 是一组增加心脏病,中风和糖尿病风险的疾病.
- 在癌症诊断后MS对RLE的影响需要进一步调查.
研究的目的:
- 为了检查代谢综合征 (MS) 组件与癌症患者的剩余预期寿命 (RLE) 之间的联系.
- 根据性别,癌症类型和多发性硬化组成部分的数量对RLE进行分层.
- 确定干预措施的潜在目标,以改善癌症幸存者的生存率.
主要方法:
- 一项使用加泰罗尼亚SIDIAP数据库的队列研究 (2006-2017年).
- 包括183,364个被诊断患有癌症的人.
- 分析了68岁的RLE,基于0,1,2或≥3个MS组件,对13种癌症类型进行了分层,按性别分层.
主要成果:
- 在68岁时,0个MS组件的男性的RLE为13.2年,而≥3个MS组件的男性的RLE为8.9年.
- 68岁,没有多发性硬化组成部分的女性的RLE为15.9年,而≥3个多发性硬化组成部分的女性的RLE为11.4年.
- 根据癌症类型和MS组件,RLE显著变化,胰腺癌显示RLE的最低值,而非霍奇金淋巴瘤显示基于MS组件的RLE的最大差异.
结论:
- 代谢综合征成分增加与癌症患者的预期寿命减少有关.
- 通过预防策略准MS组件可能会增强癌症患者的RLE.
- 个性化的生存预测和干预措施应考虑在癌症护理中的MS状态.
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