巨细胞在局部晚期的直肠癌中的作用 用新辅助化学放射治疗治疗的直肠癌
Masaaki Nishi1, Shoko Yamashita2, Chie Takasu2
1Department of Surgery, Tokushima University, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan. nishi.masaaki@tokushima-u.ac.jp.
BMC cancer
|January 17, 2025
概括
在局部晚期直肠癌中,巨细胞透与对新辅助化学放射治疗 (nCRT) 的反应不佳相关. 肥胖细胞的增加表明无病生存率较差,并促进瘤恶性,突出显示它们在治疗耐药性方面的作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 巨细胞 (MC) 在瘤微环境 (TME) 中表现出促瘤效应.
- 通过促进与瘤相关的巨细胞 (TAM) 迁移,影响瘤免疫力,MC影响瘤恶性.
研究的目的:
- 在局部晚期直肠癌 (LARC) 中,研究巨细胞透和新辅助化学放射治疗 (nCRT) 反应之间的关联.
主要方法:
- 分析了95名接受nCRT的LARC患者.
- 通过免疫组织化学 (IHC) 评估杆细胞 (酸酶) 和TAM (CD206) 蛋白质水平.
- 进行了体外测试,以评估MC对结直肠癌 (CRC) 细胞增殖和侵入的影响.
主要成果:
- 在nCRT后的LARC标本中检测到31.6%的MC透.
- 脑膜癌透与较差的nCRT反应和较低的5年无病生存率 (DFS) 有显著的相关性 (52.3%与76.8%对比).
- 麦克透独立预测了不良的DFS,并与CD206表达 (TAMs) 和通过巨抑制因子增强的CRC细胞恶性病变有关.
结论:
- 在LARC中,母细胞透与对nCRT的耐药性有关,并作为一个独立的不良预后指标.
- MC透与TAM透具有积极的相关性,并促进结直肠癌细胞的恶性行为.
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