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对帕金森病进行深度大脑刺激后,传感器记录的活动模式和神经精神症状的变化:5个病例报告:

Lena C Bruhin¹, Michael Single¹, Aileen C Naef¹

¹ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.

|January 17, 2025

概括

帕金森病 (PD) 的亚体内核深脑刺激 (STN-DBS) 影响神经精神症状. 传感器数据显示了与STN-DBS后的行为变化相关的独特活动模式.

科学领域:

神经科学是一个神经科学.
神经学神经学
生物医学工程生物医学工程

背景情况:

脑下核深度大脑刺激 (STN-DBS) 对帕金森病 (PD) 中神经精神症状的影响尚未完全理解.
对STN-DBS后行为变化的客观评估对于治疗优化至关重要.

研究的目的:

为了研究STN-DBS和PD患者的神经精神症状之间的关系.
评估传感器技术在监测STN-DBS后的行为转变中的实用性.

主要方法:

五名PD患者在STN-DBS之前和五个月后接受了全面的神经精神病学评估.
穿戴式 (智能手表) 和环境传感器监测了手术前后20天的日常活动 (步骤/小时,睡眠,户外时间).
标准化的尺度包括MDS-UPDRS III,MoCA,QIB-PD,HADS和斯塔克斯坦冷漠度尺度.

主要成果:

三名患者表现出改善的冲动-强迫行为 (ICD) 和焦虑/抑郁,与减少每天步骤和增加睡眠时间相关.
两名没有基线ICD的患者经历了轻微的焦虑/冷漠改善,对活动模式有不同的影响.
术后没有出现新的神经精神症状.

结论:

在PD患者中,STN-DBS后的行为变化与特定的活动模式有关.
可穿戴和环境传感器显示出客观地跟踪STN-DBS之后的逐渐行为转变的希望.

关键词:

深度大脑刺激是什么?神经精神病症状神经精神病症状目标评估目标评估帕金森病是帕金森氏症的一种疾病.传感器技术传感器技术

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