肠道微生物群的饮食指数与与代谢功能障碍相关的脂肪肝疾病之间的关联:一个横截面研究
Yangyang Zheng1,2, Jinhui Hou1, Shiqi Guo1,2
1Department of General Surgery, Department of Hepato-bilio-pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
较高的肠道微生物群 (DI-GM) 饮食指数得分与较低的代谢功能障碍相关脂肪肝 (MAFLD) 患病率有关. 种族可能会影响这种肠道健康和肝脏疾病的关联.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 人们越来越认识到肠道微生物在代谢功能障碍相关的脂肪肝疾病 (MAFLD) 中的作用.
- 肠道微生物群的饮食指数 (DI-GM),即微生物群多样性的衡量标准,及其与MAFLD的联系需要进一步调查.
研究的目的:
- 调查肠道微生物群的饮食指数 (DI-GM) 与MAFLD的流行率之间的关联.
- 探索这种关系中潜在的修改因素,如种族.
主要方法:
- 分析了2017-2020年国家健康和营养检查调查 (NHANES) 7243名参与者的数据.
- 利用加权后勤回归,限制立方线 (RCS) 分析和子组分析来检查DI-GM和MAFLD的关联.
主要成果:
- 在DI-GM和MAFLD患病率之间发现了反向关联;每一个1点的DI-GM增加与6.1%的MAFLD减少相关 (OR=0.939).
- 与得分为0-3 (OR=0.794) 的人相比,DI-GM得分≥6的个体对MAFLD的调整几率明显较低.
- RCS分析显示出线性关系,子组分析确定种族是显著的修饰因素 (P<0.05).
结论:
- 肠道微生物群的饮食指数 (DI-GM) 与MAFLD患病率相反相关.
- 种族显著改变了DI-GM和MAFLD之间的关系,突出了肠道健康和肝脏疾病的潜在差异.
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