系统性免疫炎症指数和表型年龄加速与慢性呼吸道疾病的联合关联:一个横截面研究
Yuan Zhan1, Ruonan Yang2, Jie Feng3
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
BMC public health
|January 17, 2025
概括
较高的全身免疫炎症指数 (SII) 和表型衰老加速 (PhenoAgeAccel) 与慢性呼吸道疾病 (CRD) 有关. 对SII和PhenoAgeAccel的联合评估有助于识别CRD早期预防的风险人群.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 免疫学 免疫学 免疫学
- 老年学是指老年学的学科.
背景情况:
- 慢性呼吸道疾病 (CRD) 构成了全球重大健康负担.
- 系统性炎症和表型衰老独立地与CRD相关.
- 炎症和衰老对CRD的综合影响仍未得到充分研究.
研究的目的:
- 研究系统性免疫炎症指数 (SII) 和表型年龄加速 (PhenoAgeAccel) 与CRD的联合和相互调解的关联.
- 为这些协会分析国家健康和营养检查调查 (NHANES) 的数据.
主要方法:
- 使用了2007-2010年和2015-2018年的NHANES数据.
- 使用多变量逻辑回归和受限立方线 (RCS) 进行关联和剂量反应分析.
- 进行了子组和调解分析,以探索相互影响.
主要成果:
- 分析了15,075名参与者 (3,587名CRD患者);CRD患者的SII和PhenoAgeAccel更高.
- 无论是SII还是PhenoAgeAccel,都与CRD有积极的联系.
- 结合较高的SII和PhenoAgeAccel显示,与CRD,COPD和喘的相关性更强,特别是在40岁以上的个人,女性和吸烟者中.
- 调解分析表明,PhenoAgeAccel显著调解了SII对CRD的影响.
结论:
- 在CRD中确认了SII和PhenoAgeAccel之间的共同暴露效应和相互调解.
- 对SII和PhenoAgeAccel的联合评估可以改善对CRD敏感人群的识别.
- 建议对慢性呼吸道疾病的早期预防策略进行综合评估.
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