药房的实用性评估,以剂量达普托米辛协议:一个追溯的队列研究
Kevin Burnham1, Stefanie Henley1, Matthew P Crotty2
1Department of Pharmacy, Methodist Charlton Medical Center, Methodist Health System, Dallas, TX, USA.
The Annals of pharmacotherapy
|January 18, 2025
概括
药房到剂量 (PTD) 服务改善了达普素的剂量. 这项研究发现,PTD服务显著增加了患者适当的初始剂量和肌酸化酶监测.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 传染性疾病 传染性疾病
背景情况:
- 药房到剂量 (PTD) 服务包括对药物剂量进行药剂师咨询.
- 2019年批准的一项达普托米辛协议使药剂师能够根据指示,功能和BMI调整剂量.
研究的目的:
- 为了评估达普托米辛PTD的有效性,请咨询服务.
- 为了确定PTD服务是否可以提高初始达普托米辛剂量的准确性.
主要方法:
- 在4家社区医院对297名患者的回顾性分析 (2019年7月-2021年10月).
- 两个队列的比较:接受达普托米辛的患者与PTD服务和没有PTD服务.
- 主要终点:具有适当初始达普托米辛剂量的患者比例.
主要成果:
- 与非PTD组 (82.8%;P=0.02) 相比,PTD组的适当初始达普托米辛剂量显著更高 (92.2%).
- 在PTD组中,基线肌酸化酶 (CPK) 监测的频率明显高于PTD组 (88.3%与77.5%相比;P=0.02).
- 在24小时剂量调整方面,有一种趋势有利于PTD臂,尽管在统计学上并不显著 (80%对58.3%;P=0.22).
结论:
- 达普托米辛PTD方案显著增加了适当的初始剂量.
- 与传统供应商订单输入相比,PTD服务增强了基线CPK监控.
- PTD服务在优化达普米辛治疗方面显示出实用性.
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