相关实验视频

Updated: Jun 1, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

血清甲状腺蛋白作为甲状腺功能过强症差异诊断的标记物

Fatimah Javaid Qureshi^1,2, Muhammad Anwar^1,2, Muhammad Qaiser Alam Khan^1,2

¹Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|January 18, 2025

概括

血清甲状腺蛋白 (TG) 水平有效地区分甲状腺功能障碍的原因,在甲状腺炎中显示最高水平,在格雷夫斯病中显示最低水平. 这有助于诊断各种甲状腺功能障碍.

科学领域:

内分泌学和化学病理学
甲状腺疾病诊断诊断甲状腺疾病诊断

背景情况:

甲状腺功能障碍是一种常见的内分泌疾病,具有不同的病因.
甲状腺球蛋白 (TG) 是甲状腺细胞产生的蛋白质,其血清水平可以反映甲状腺活动.
区分甲状腺功能障碍的原因对于适当的患者管理至关重要.

研究的目的:

评估血清甲状腺蛋白 (TG) 作为高甲状腺症差异诊断的生物化学标记物的实用性.
研究血清TG水平与甲状腺功能障碍的特定原因之间的关系.

主要方法:

一项涉及148名甲状腺功能障碍患者的比较横截面研究.
使用化学发光免疫试验测量血清TG水平.
甲状腺扫描被用来确定甲状腺功能障碍的病因,通过克鲁斯卡尔-瓦利斯测试进行统计分析.

主要成果:

在76.3%的患者中观察到血清TG水平升高 (>42 ng/ml).
平均TG水平因病因而有显著差异:甲状腺炎 (202.5 ng/ml) 处于最高水平,其次是有毒腺瘤 (139 ng/ml) 和有毒多节 (102 ng/ml),格雷夫斯病 (34 ng/ml) 处于最低水平.
甲状腺蛋白在检测甲状腺疾病方面表现出76%的灵敏度和100%的特异性,PPV为100%和NPV为20.45%.

结论:

血清TG水平在不同甲状腺功能障碍的原因之间表现出明显的变化.
甲状腺炎与最高血清TG水平相关,而格雷夫斯病显示最低.
血清TG是一种有价值的生物化学标记物,用于区分甲状腺功能过高的病因.

更多相关视频

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...