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手术前炎症标记在子宫圆成功中的作用

Gulten Ozgen¹, Levent Ozgen², Burcu Dincgez¹

¹Department of Obstetrics and Gynaecology, Health Sciences University, Bursa Yuksek Ihtisas Training and Research Hospital, <br> Bursa, Turkiye.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

|January 18, 2025

概括

与治疗性 cerclage 相比,紧急 cerclage 与更高的炎症标志物和更短的潜伏期有关. 系统性免疫炎症指数可以预测经过宫 cerclage 的患者的新生儿死亡率和发病率.

科学领域:

产科和妇科产科和妇科
产周医学产周医学
免疫学免疫学免疫学

背景情况:

子宫带是预防早产的一种手术.
炎症标志物可能在宫 cerclage 的成功中发挥作用.
在不同类型的 cerclage 之间比较炎症标志物对于理解结果很重要.

研究的目的:

为了比较治疗和紧急情况下的炎症标志物.
评估炎症标志物在 cerclage 后的潜伏期的预测作用.
评估炎症标志物与围产期结局的关联.

主要方法:

一项描述性研究,比较治疗 (n=64) 和急救 (n=14) cerclage 组.
排除标准包括多胎妊娠,活跃收缩,出血和感染.
测量和比较了炎症标志物,包括中性粒细胞与淋巴细胞的比率和全身免疫炎症指数.

主要成果:

紧急 cerclage 与治疗 cerclage (20 周) 相比,潜伏期 (5.5 周) 显著较短.
中性粒细胞与淋巴细胞的比率和全身免疫炎症指数在紧急 cerclage 组显著更高.
系统性免疫炎症指数预测新生儿死亡率 (AUC=0.776) 和低的阿帕尔分数 (AUC=0.641).

结论:

系统性免疫炎症指数是预测新生儿死亡率和患病率的潜在标志物.
较高的炎症标志物与紧急 cerclage 和较差的围产期结果有关.
需要进一步的研究来阐明炎症在宫衰竭和宫结合结果中的作用.

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