在冠状病毒疾病-19大流行期间,在通风患者中出现多种耐药生物的频率和模式
Faiza Rezwan1,2,3, Tazeen Fatima1,2,3, Farheen Ali4
1Department of Medical Microbiology, National Institute of Cardiovascular Diseases, Karachi, Pakistan.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|January 18, 2025
概括
多种耐药性 (MDR) 细菌在通风患者中很常见,特别是型阳性菌. COVID-19患者也显示出显著的MDR患病率,突出显示了对抗生素耐药性监测的需要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 呼吸机相关肺炎 (VAP) 是重症监护室的一个重大问题.
- 多药耐药 (MDR) 生物对患者的治疗结果构成越来越大的威胁.
- 在重症监护机构中MDR细菌的出现需要持续监测.
研究的目的:
- 为了确定MDR细菌分离物的频率,从通风患者的呼吸道样本.
- 在COVID-19阳性和阴性患者中分析MDR流行率.
- 为了比较格拉姆阴性杆菌 (GNR) 和格拉姆阳性菌 (GPC) 之间的MDR率.
主要方法:
- 在国家心血管疾病研究所 (NICVD) 从2021年11月到2022年3月进行的观察性研究.
- 分析来自重症监护和手术重症监护病房的气管吸血和支气管膜洗 (BAL) 样本.
- 使用基平方测试,GNR和GPC之间MDR流行率的统计比较.
主要成果:
- 在662个样本中,确定了229个细菌分离物:171个GNR和58个GPC.
- 总体上,MDR的流行率在GNR中为22%,在GPC中为38%.
- 在COVID-19阳性患者中,MDR患病率约为11%.
结论:
- 在通风患者中发现了显著的MDR细菌分离的频率,特别是GPC菌株.
- 在COVID-19患者中MDR的流行需要警的监测和干预策略.
- 解决这种敏感群体中抗生素耐药性的问题对于改善患者护理至关重要.
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