在MS的上脊髓缩:性别,更年期和神经退行症
Burcu Zeydan1,2,3, Jiye Son1, Nur Neyal1
1Department of Radiology, Mayo Clinic, Rochester, MN, USA.
概括
脊髓缩与多发性硬化症 (MS) 患者的男性性别和更年期有关. 这些因素,以及年龄和疾病持续时间,与MS患者的神经退行症的增加有关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 脊髓缩是进展性多发性硬化症 (MS) 的关键成像生物标志物.
- 渐进性多发性硬化不成比例地影响男性和绝经后妇女.
研究的目的:
- 调查性别和更年期如何影响MS (pwMS) 患者的脊髓测量.
- 检查pwMS中SC测量,疾病进展和残疾之间的关联.
主要方法:
- 在pwMS和年龄/性别匹配的对照中,从脑MRI (UCC大脑) 中测量了宫上脊髓区域.
- 分析了性别和更年期对UCC大脑的影响,以总内体积进行调整.
- 研究了UCC大脑和MS进展标志物 (例如MS功能复合物) 之间的关联.
主要成果:
- 与对照组相比,pwMS中的UCC大脑明显较小.
- 较小的UCC大脑观察到男性与女性,绝经后与绝经前妇女,以及进展性MS与复发性MS.
- UCC大脑与年龄,疾病持续时间和9洞杆测试的表现相反相关,并且与严重的门诊残疾有关.
结论:
- UCC是渐进性多发性硬化症的一个有价值的生物标志物,与年龄,疾病持续时间,男性性别和更年期有反向关联.
- 这些发现表明,性别和荷尔蒙因素在MS神经退行症中起着重要作用.
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