婴儿早产与儿童自闭症谱系障碍之间的关联:一项回顾性队列研究
Sapir Ellouk1,2, Omri Zamstein1, Tamar Wainstock2
1Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
概括
这项研究发现,早产和儿童自闭症谱系障碍 (ASD) 诊断之间没有显著的联系. 需要进一步的研究来了解早产婴儿的神经发育结果.
科学领域:
- 围产期流行病学 围产期流行病学
- 儿童神经学 儿童神经学
- 发育儿科 发育儿科
背景情况:
- 过早产生的并发症是婴儿死亡率和发病率的主要原因.
- 过早出生 (PTB) 和自闭症谱系障碍 (ASD) 之间的关系尚未得到充分证实.
研究的目的:
- 调查早产 (PTB) 与儿童自闭症谱系障碍 (ASD) 诊断之间的关联.
主要方法:
- 一项回顾性队列研究分析了2005年至2017年间114,975次分娩的数据.
- 在各种妊娠年龄类别中对ASD发病率进行了比较:极度早产 (<28周),非常早产 (28-32周),中度至晚期早产 (32-37周) 和终产 (≥37周).
- 调整后的Cox比例危险模型和Kaplan-Meier生存曲线被用于评估关联,控制混因素.
主要成果:
- 无变量分析表明PTB和ASD之间存在潜在的关联.
- 然而,经过调整的分析显示,任何类别的早产和儿童ASD诊断之间没有统计学上显著的关联.
- 卡普兰-梅尔分析还显示,所有妊娠年龄组的ASD累积发病率相似.
结论:
- 这项研究得出的结论是,早产和儿童中自闭症谱系障碍的诊断之间没有显著的关联.
- 这些发现有助于关于早产婴儿神经发育结果的持续辩论.
相关概念视频
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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01:28Conduct Disorder
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