在代表不足的拉丁美洲帕金森病患者群体中,对全球认知表现的差异和贡献者
Saar Anis1, Henry Mauricio Chaparro-Solano2,3, Thiago Peixoto Leal2
1Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
The Clinical neuropsychologist
|January 18, 2025
概括
患有帕金森病 (PD) 的拉丁裔患者的认知分数低于非西班牙裔白人PD患者和拉丁裔对照. 教育和症状发作等因素会影响PD患者的认知表现.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 认知障碍是帕金森病 (PD) 的一个常见的非运动症状.
- 现有的PD认知功能研究缺乏拉丁裔人口的代表性.
- 了解PD认知表现的种族差异对于公平的医疗保健至关重要.
研究的目的:
- 调查拉丁裔患有PD患者认知表现的贡献者和差异.
- 为了比较拉丁裔PD患者,白人非西班牙裔PD患者和拉丁裔对照患者之间的认知分数.
- 为了确定与拉丁裔PD患者认知表现相关的因素.
主要方法:
- 来自LARGE-PD和PPMI队列的横截面数据的回顾性分析.
- 包括人口,环境,运动和非运动疾病特征.
- 线性回归多变量模型用于评估影响蒙特利尔认知评估 (MoCA) 成绩的因素.
主要成果:
- 与白人非西班牙裔PD患者和拉丁裔对照患者相比,拉丁裔PD患者的MoCA得分明显较低 (p < .001).
- 与拉丁-PD中更好的MoCA分数相关的因素包括单方面症状发作和高等教育.
- 较差的MoCA分数与多巴胺激动剂使用,以前的烟草使用,年龄较大以及更高的Hoehn和Yahr分数有关.
结论:
- 与其他群体相比,拉丁裔PD患者表现出显著的认知缺陷.
- 在PD的认知评估需要在不同人群中进行细微的解释.
- 解决PD护理中的差异需要对认知评估采取文化敏感的方法.
相关概念视频
01:27Language and Cognition
321
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
321
01:15Parkinson's Disease: Overview
456
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
456
01:24Parkinson's Disease: Treatment
202
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
202