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Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
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相关实验视频

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The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
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在儿科发病的多发性硬化症中,腹腔下区域微结构.

Monica Margoni1,2,3, Loredana Storelli1, Elisabetta Pagani1

  • 1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Annals of neurology
|January 18, 2025
PubMed
概括
此摘要是机器生成的。

腹腔下区域 (SVZ) 微结构变化发生在儿科多发性硬化症 (MS) 的早期,与大脑损伤相关,但不是临床损伤. 这些发现突显了小儿多发性硬化症患者SVZ中与疾病相关的早期变化.

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科学领域:

  • 神经科学是一个神经科学.
  • 放射学 放射学是一门学科.
  • 神经学 神经学

背景情况:

  • 腹腔下区域 (SVZ) 是一个关键的神经性.
  • 衰老影响SVZ微观结构,影响神经发生和大脑健康.
  • 儿科发病多发性硬化症 (MS) 在了解疾病进展方面提出了独特的挑战.

研究的目的:

  • 调查SVZ中与年龄相关的微观结构变化.
  • 检查SVZ微观结构与儿科MS中的临床残疾之间的关联.
  • 探索SVZ变化与儿科MS中大脑结构损伤之间的关系.

主要方法:

  • 141名儿科发病的MS患者和233名健康对照 (HC) 接受了3.0T的MRI.
  • 在SVZ和thalamus中测量了分数异构性 (FA) 和平均扩散性 (MD).
  • 分析与临床残疾和脑损伤体积相关的微观结构指标.

主要成果:

  • 在健康的对照组中,SVZ微观结构随着年龄的增长而变化,FA和MD的不同模式.
  • 儿科多发性硬化患者与儿科高发性硬化患者相比,表现出更高的SVZ FA,而成年患者没有显示出差异.
  • 在MS患者中SVZ和乳头微观结构异常与白质病变体积和大脑体积减少相关.

结论:

  • 在儿科MS中,SVZ微观结构变化很早就显而易见.
  • 这些早期的SVZ变化与大脑结构损伤有关.
  • 在儿科MS中SVZ微结构变化似乎与临床损伤无关.