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在儿科发病的多发性硬化症中,腹腔下区域微结构
Monica Margoni1,2,3, Loredana Storelli1, Elisabetta Pagani1
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Annals of neurology
|January 18, 2025
概括
腹腔下区域 (SVZ) 微结构变化发生在儿科多发性硬化症 (MS) 的早期,与大脑损伤相关,但不是临床损伤. 这些发现突显了小儿多发性硬化症患者SVZ中与疾病相关的早期变化.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 神经学 神经学
背景情况:
- 腹腔下区域 (SVZ) 是一个关键的神经性.
- 衰老影响SVZ微观结构,影响神经发生和大脑健康.
- 儿科发病多发性硬化症 (MS) 在了解疾病进展方面提出了独特的挑战.
研究的目的:
- 调查SVZ中与年龄相关的微观结构变化.
- 检查SVZ微观结构与儿科MS中的临床残疾之间的关联.
- 探索SVZ变化与儿科MS中大脑结构损伤之间的关系.
主要方法:
- 141名儿科发病的MS患者和233名健康对照 (HC) 接受了3.0T的MRI.
- 在SVZ和thalamus中测量了分数异构性 (FA) 和平均扩散性 (MD).
- 分析与临床残疾和脑损伤体积相关的微观结构指标.
主要成果:
- 在健康的对照组中,SVZ微观结构随着年龄的增长而变化,FA和MD的不同模式.
- 儿科多发性硬化患者与儿科高发性硬化患者相比,表现出更高的SVZ FA,而成年患者没有显示出差异.
- 在MS患者中SVZ和乳头微观结构异常与白质病变体积和大脑体积减少相关.
结论:
- 在儿科MS中,SVZ微观结构变化很早就显而易见.
- 这些早期的SVZ变化与大脑结构损伤有关.
- 在儿科MS中SVZ微结构变化似乎与临床损伤无关.
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