在动脉样硬化多民族研究 (MESA) 中,对感知歧视的全表观基因组关联研究
Wei Zhao1,2, Lisha Lin2, Kristen M Kelly3
1Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Epigenetics
|January 18, 2025
概括
感知到的歧视可能会改变DNA甲基化 (DNAm),这是一种将压力与健康联系起来的分子机制. 这项研究确定了与歧视相关的特定DNAm位点,可能影响基因表达和疾病风险.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 心理社会压力 心理社会压力
- 基因组学就是基因组学.
背景情况:
- 感知到的歧视是一种具有负面健康影响的慢性压力因素.
- 基因甲基化 (DNAm) 是一种分子机制,将压力因素与健康结果联系起来.
- 关于被认为是歧视对DNAm的影响的研究有限.
研究的目的:
- 为了确定与感知歧视相关的DNA甲基化部位.
- 研究不同种族/族群的歧视与DNAm之间的关系.
主要方法:
- 全表观基因组关联分析 (EWAS) 对来自动脉样硬化多民族研究 (MESA) 的1151名参与者进行.
- 评估了三种被认为是歧视的措施:日常,与种族有关的重大歧视,以及与种族无关的重大歧视.
- 分析包括种族/种族分层和跨祖先的元分析.
主要成果:
- 七个CpG和四个差异甲基化区域 (DMR) 与10%的错误发现率与感知歧视有关.
- 这些部位和相关的基因与细胞发育,转录因子结合,癌症和自身免疫/炎症性疾病有关.
- 在一个DMR中,两个CpG和一个CpG与cis基因的表达有关 (NDUFS5,AK1RIN1,NCF4,ADSSL1).
结论:
- 歧视对DNA甲基化模式有潜在的影响.
- 与歧视相关的DNAm变化可能会影响基因表达.
- 这项研究突出了将心理社会压力与健康结果联系起来的分子途径.
相关概念视频
Stereotypes, Prejudice, and Discrimination
90.1K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
90.1K
Surveys
14.7K
Often, psychologists develop surveys as a means of gathering data. Surveys are lists of questions to be answered by research participants, and can be delivered as paper-and-pencil questionnaires, administered electronically, or conducted verbally. Generally, the survey itself can be completed in a short time, and the ease of administering a survey makes it easy to collect data from a large number of people.
14.7K
Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
Epistasis Analysis
4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K
Ethnic Identity within a Larger Culture
30
Adolescents from ethnic minority backgrounds face a multifaceted journey in forming their identities, shaped by the intersections of cultural expectations and personal exploration. For these adolescents, identity formation involves not only typical developmental challenges but also navigating the perceptions and attitudes of the majority culture. As they grow, adolescents in ethnic minority groups often become increasingly aware of stereotypes, social biases, and discrimination, all of which...
30
Stereotype Content Model
14.0K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
14.0K


