局部和全身治疗对牛皮内介质厚度的影响
Elif Cansel Gumus1, Ugur Celik2, Selim Gumus3
1Cerrahpasa Faculty of Medicine, Department of Dermatology, Istanbul University-Cerrahpasa, Istanbul, Turkey. elifcanselozcakir@gmail.com.
Archives of dermatological research
|January 18, 2025
概括
针对性全身疗法通过降低动脉内心介质厚度,显著减少了牛皮患者的亚临床动脉样硬化. 局部治疗没有显示这种益处,强调了牛皮的全身性质及其心血管影响.
科学领域:
- 皮肤病学 皮肤病学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 牛皮与心血管疾病和死亡率的增加有关,部分原因是慢性炎症.
- 亚临床动脉样硬化,是心血管事件的前体,在牛皮患者中很普遍.
- 早期发现和治疗动脉样硬化对于改善这一群体的治疗结果至关重要.
研究的目的:
- 在牛皮患者中评估亚临床动脉样硬化.
- 评估针对性全身疗法与局部治疗对动脉样硬化的影响.
- 为了将治疗效果与动脉内心介质厚度 (CIMT) 变化相关联.
主要方法:
- 研究了一组105名牛皮患者的队列.
- 在基线和6个月治疗后测量了心动脉内膜-介质厚度 (CIMT).
- 患者接受了向的全身疗法 (secukinumab,ixekizumab,guselkumab,risankizumab) 或局部治疗.
主要成果:
- 有针对性的全身疗法 (secukinumab,ixekizumab,guselkumab,risankizumab) 导致CIMT显著减少.
- 局部治疗与CIMT的增加有关.
- 这些发现表明,治疗方式对亚临床动脉样硬化有不同的影响.
结论:
- 有针对性的全身治疗可以改善牛皮患者的亚临床动脉样硬化.
- 局部治疗没有证明对动脉样硬化有类似的益处.
- 牛皮是一种全身性炎症性疾病,具有重大心血管影响,需要全面管理.
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