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Updated: Jun 1, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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帕尔米通过降低核GDF15水平来增强SMAD3-PAI-1通路

Marta Montori-Grau1,2,3,4, Emma Barroso1,2,3,4, Javier Jurado-Aguilar1,2,3,4

  • 1Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Unitat de Farmacologia, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028, Barcelona, Spain.

Cellular and molecular life sciences : CMLS
|January 18, 2025
PubMed
概括

像palmitate这样的和脂肪酸减少了核GDF15,激活了SMAD3-PAI-1通路. 这种机制促进了骨肌肉的胰岛素抵抗,在高脂肪饮食中的GDF15缺乏的小鼠中恶化了葡萄糖不耐受性.

关键词:
在GDF15中,GDF15是GDF15中的一个.胰岛素耐药性 胰岛素耐药性是一种肌肉 肌肉 肌肉 肌肉油酸盐是一种油酸盐.PAI-1是PAI-1的第一个类型.棕酸盐是一种棕酸盐.在SMAD3中,我们可以看到SMAD3.

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