常规甲状腺功能检测肠道症状的低效益:基于人口的评估
Ahmed D Elnaiem1,2, Brent Hiramoto1,2, Ryan Flanagan1,2
1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Digestive diseases and sciences
|January 18, 2025
概括
甲状腺功能障碍不是便秘或腹的重要预测因素. 然而,较高的自由T4水平可以防止便秘,甲状腺功能障碍与便失禁有关.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 慢性便秘,腹和便失禁 (FI) 显著影响生活质量.
- 甲状腺功能障碍被怀疑是导致肠道乱的原因之一,但证据不一致.
研究的目的:
- 为了检查甲状腺功能和肠道健康之间的关联,在美国全国代表性样本中.
- 研究甲状腺刺激激素 (TSH),自由甲状腺素 (fT4) 和肠道症状之间的联系.
主要方法:
- 2005-2008年国家健康和营养检查调查 (NHANES) 数据的横截面分析.
- 包括20岁以上的成年人,TSH,FT4和肠道健康数据.
- 使用多变量逻辑回归,对混因素进行调整.
主要成果:
- 对于便秘或腹的甲状腺功能障碍患病率没有显著差异.
- TSH不是便秘,腹或FI的重要预测因素.
- 较高的FT4对便秘有保护作用 (OR 0.47).
- 甲状腺功能障碍与便失禁有关 (OR 3.58).
结论:
- 肠道障碍很常见,但甲状腺功能测试对这些症状的产量很低.
- 过度的甲状腺功能低下症和甲状腺功能增强症与便秘或腹没有显著的联系.
- 在没有系统性甲状腺疾病症状的情况下,常规甲状腺检测肠道症状可能缺乏临床实用性.
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