在患有代谢功能障碍相关的脂肪肝疾病 (MASLD) 的患者中,sarcopenic肥胖的临床相关性
Shih-Chieh Chien1,2, Hung-Chih Chiu2, Yen-Cheng Chiu2
1Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 70401, Taiwan.
Digestive diseases and sciences
|January 18, 2025
概括
麻性肥胖 (SO) 影响了近一半的代谢功能障碍相关的脂肪性肝病 (MASLD) 患者. 在这些患者中,SO显著增加了心血管疾病的风险.
科学领域:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD)
- 标本性肥胖症 (SO) 是一种肥胖症.
- 心血管疾病 (CVD) 的风险
背景情况:
- 麻性肥胖症 (SO) 与各种患者群体的不良结果有关.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 了解SO和MASLD之间的相互作用对于患者管理至关重要.
研究的目的:
- 为了确定患有MASLD的患者中型肥胖 (SO) 的患病率.
- 在这个人群中确定与SO相关的风险因素.
- 调查SO对MASLD患者心血管疾病 (CVD) 风险的影响.
主要方法:
- 这是一项涉及223名患有MASLD的患者的横截面研究.
- 双能X射线吸收计 (DXA) 用于身体组成分析.
- 使用10年动脉样硬化心血管疾病 (ASCVD) 风险评分评估心血管风险.
主要成果:
- 在MASLD患者中,SO的患病率为47.1%.
- SO与内脏脂肪组织 (VAT) 的增加,脂肪肝指数 (FLI) 和FIB-4分数的增加有关.
- 患有SO的MASLD患者表现出更高的10年ASCVD风险得分 (10.1%与7.3%相比),增加的VAT和FIB-4与更高的ASCVD风险有关.
结论:
- 麻性肥胖症 (SO) 在患有MASLD的患者中非常普遍.
- SO的存在是MASLD患者心血管疾病 (CVD) 风险增加的重要危险因素.
- 临床识别和SO的管理对于改善MASLD患者的结果至关重要.
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