多发性骨髓瘤患者的侵入性真菌病:大型城市推中心的经验
Emily Baneman1, Alan Weinberg2, Timothy Sullivan1
1Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
概括
多发性骨髓瘤 (MM) 患者的侵入性真菌病 (IFD) 风险较低,但进展性疾病和中性质衰竭是关键的风险因素. 这项研究提供了对IFD流行病学和该人口的风险因素的最大分析.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 感染是多发性骨髓瘤 (MM) 发病率和死亡率的主要原因.
- 与其他血液性恶性瘤相比,MM中的侵入性真菌病 (IFD) 的流行病学知之甚少.
研究的目的:
- 在多发性骨髓瘤患者中描述IFD的流行病学.
- 在这个患者群体中识别与IFD相关的风险因素.
主要方法:
- 进行了一个嵌套的3:1病例控制研究.
- 2011年1月至2019年6月期间从大型MM推中心收集的数据.
- 在2960名MM患者的队列中,在31名患者中确定了32次IFD发作.
主要成果:
- 从MM诊断到IFD的中位时间为3.6年,前4次化疗线的中位数为3.6年.
- IFD的重要风险因素包括进展性疾病状态 (OR 1.35) 和中性质衰竭 (OR 17.5).
- 最常见的真菌病因是Aspergillus物种 (n=18),其次是Candida (n=6).
结论:
- 这项研究提供了对MM患者IFD流行病学的最大程度的详细描述.
- 渐进性疾病和中性衰竭是该人群中IFD的重要危险因素.
- 在多发性骨髓瘤患者中,IFD的总体风险被发现很低.
相关概念视频
Infection
11.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.7K
Factors Affecting the Risk of Infection
14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Pulmonary Tuberculosis I
1.7K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
Pulmonary Tuberculosis V
1.0K
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
1.0K


