维生素D缺乏可能会加速女性非载体阿波利波蛋白E ε4的认知衰退
Jiwon Kim1, Eunjeong Ji2, Jong Bin Bae3
1Department of Brain and Cognitive Science, Seoul National University, Seoul, Republic of Korea.
Clinical nutrition (Edinburgh, Scotland)
|January 18, 2025
概括
维生素D缺乏 (VDD) 加快了老年人的认知衰退,特别是在没有APOE ε4基因的女性中. 这凸显了保持大脑健康的个性化策略的必要性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 维生素D缺乏 (VDD) 对认知的影响受到争论.
- 阿波蛋白E (APOE) ε4状态和性别可能会影响VDD的认知影响.
- APOE ε4 影响维生素 D 的代谢,女性对维生素 D 的敏感性更高.
研究的目的:
- 研究APOE ε4,性别和VDD在认知衰退中的相互作用.
- 分析VDD的老年人的认知变化.
- 确定APOE ε4状态和性别是否会改变VDD与认知之间的关联.
主要方法:
- 基于人口的队列研究,对1547名60岁以上认知正常的韩国人进行了研究.
- 两年一度的迷你精神状态检查 (MMSE) 追踪从2010年到2020年.
- VDD定义为血清25-基维生素D<10 ng/mL;使用线性混合模型分析,并对APOE ε4和性别进行亚组分析.
主要成果:
- 21.3%的参与者患有VDD,与更快的MMSE下降有关.
- 在非载体APOE ε4中,VDD的负面影响是显著的.
- 这种关联在女性非载体中尤为明显,但在男性非载体中并不显著.
结论:
- 在认知上正常的APOE ε4非载体中,VDD加速认知衰退.
- 这种效应在女性中尤为明显.
- 针对VDD的量身定制的预防策略对于维护风险人群的认知健康至关重要.
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