1999-2018年NHANESES研究的身体圆度指数和中风结果之间的关联
Jiale Gan1, Xinyi Yang1, Jianan Wu2
1Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China; Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.
概括
身体圆度指数 (BRI) 显示,在美国成年人中,与中风发病率有非线性正相关性. 较高的BRI水平与中风风险增加相关,表明其作为查工具的潜力.
科学领域:
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
- 肥胖研究的研究.
背景情况:
- 内脏肥胖是中风的重要危险因素.
- 传统的人类测量方法在评估脂肪分布方面存在局限性.
- 身体圆度指数 (BRI) 为评估身体脂肪百分比和内脏脂肪组织提供了一种新的方法.
研究的目的:
- 调查身体圆度指数 (BRI) 与美国人口中卒中发生率之间的关联.
- 为了确定BRI是否可以作为中风风险的预测指标.
主要方法:
- 一项队列研究利用来自美国国家健康和营养检查调查 (NHANES) (1999-2018) 的39,454名美国成年人 (年龄≥20岁) 的横截面数据.
- 使用加权后勤回归和限制立方线回归 (RCS) 来分析BRI和中风之间的关系.
- 进行了子组分析和相互作用测试,以探索协会中的潜在变异.
主要成果:
- 在BRI和中风发病率之间发现了积极的关联 (OR = 1.057每单位增加BRI,P = 0.020).
- RCS分析表明非线性关系,在BRI转折点8.489.9之前观察到较高的中风风险.
- 积极的相关性在各种子组和相互作用中保持一致.
结论:
- 在美国成年人中,BRI与中风风险之间存在非线性正相关性.
- BRI可能是评估中风风险的有价值的查工具.
- 由于横截面研究的局限性,建议在独立队列中进一步验证.
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