室内灰尘引发的粘膜屏障功能障碍和2型炎症反应通过MAPK/AP-1/IL-24通过过敏性鼻炎的信号通路
Siyao Zhang1, Wanjuan Wu1, Min Gu1
1Department of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, 71 Hexi Street, Nanjing 210019, Jiangsu, China; Nanjing Medical Key Laboratory of Laryngopharynx & Head and Neck Oncology, 71 Hexi Street, Nanjing 210019, Jiangsu, China.
International immunopharmacology
|January 18, 2025
概括
室内灰尘虫 (HDM) 暴露会损害过敏性鼻炎 (AR) 中的鼻上皮质屏障. 介质素-24 (IL-24) 通过破坏屏障功能和促进炎症来加剧AR,这表明IL-24通路调节是潜在的治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 过敏研究 研究过敏
背景情况:
- 表皮屏障对于免疫反应和炎症调节至关重要,而不仅仅是身体防御.
- 过敏性鼻炎 (AR) 是一种常见的鼻炎,常常由室内灰尘 (HDM) 过敏原引发,这些过敏原会破坏这种屏障.
- 介质素-24 (IL-24) 涉及过敏性疾病和上皮平衡,但其在AR中的确切作用尚不清楚.
研究的目的:
- 研究HDM诱导的IL-24分泌机制及其对AR鼻膜屏障功能的影响.
- 阐明HDM介导IL-24产生的信号通路,以及IL-24对屏障完整性的下游影响.
- 探索针对IL-24途径用于AR治疗策略的潜力.
主要方法:
- 对患者和动物组织样本的分析,这些样本来自HDM敏感的个体.
- 研究IL-24分泌途径,包括P38 MAPK和AP-1.
- 通过STAT1/STAT3信号传递和IL-33分泌,研究IL-24对上皮屏障蛋白 (occludin,ZO-1) 的作用.
主要成果:
- 高密度敏会诱导鼻腔炎症并增加IL-24分泌,与AR严重程度相关.
- HDM通过P38 MAPK/AP-1通路增强IL-24的产生.
- IL-24通过STAT1/STAT3减少奥克卢丁和ZO-1的表达,增加透性并促进IL-33的分泌,从而放大炎症.
结论:
- IL-24是HDM诱导过敏性鼻炎的关键调解剂,破坏了上皮质屏障功能并加剧了2型炎症.
- 这项研究阐明了在HDM敏感的AR中表皮屏障损伤背后的分子机制.
- 调节IL-24信号通路为恢复屏障完整性和管理AR提供了潜在的治疗途径.
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