三糖糖体质量指数与与记忆有关的疾病之间的关联:一项全国性的队列研究
Xiaoyan Ni1, Yiwei Zhang1, Weixian Zhang1
1Department of Pediatrics, The People's Hospital of Chongqing Liang Jiang New Area, Chongqing, 401121, China.
高 triglyceride糖体质量指数 (TyG-BMI) 与中国成年人患记忆相关疾病 (MDs) 的风险增加有关. 监测TyG-BMI可能有助于早期MDs的识别和预防.
科学领域:
- 代谢健康和神经系统疾病.
- 慢性疾病的流行病学.
- 在衰老中的生物标志物研究.
背景情况:
- 三糖糖-体质指数 (TyG-BMI) 是一种新的胰岛素抵抗性指标.
- 与记忆相关的疾病 (MDs) 构成了重大的公共卫生挑战,特别是在老年人群中.
- 了解MD的新风险因素对于制定有效的预防策略至关重要.
研究的目的:
- 研究TyG-BMI指数与中国成年人群中与记忆相关疾病 (MDs) 的发生率之间的纵向关联.
- 为了确定提升的TyG-BMI是否是随着时间的推移发展MD的独立风险因素.
主要方法:
- 一项全国性的队列研究利用了中国健康与退休纵向研究 (CHARLS) 的数据.
- 基线TyG-BMI是从2011-2012年的数据计算出来的;MDs是在2018年自我报告的.
- 考克斯的比例危险回归模型被用于分析关联,并对潜在的混因素进行调整.
主要成果:
- 在7.0年的中位数随访期间,记录了197起MD事件事件.
- 在多变量调整后,TyG-BMI的最高三位数与MDs风险增加1.65倍 (95% CI:1.02-2.09) 与最低三位数相比显著相关.
- 小组分析证实了这种关联的一致性.
结论:
- 高的TyG-BMI指数与患有与记忆有关的疾病的风险增加长度相关.
- 泰格-BMI指数可以作为一种有价值的生物标志物,用于在风险人群中早期识别和预防MDs.
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