针对YAP/TAZ-TEAD信号作为头部和部状细胞癌的治疗方法

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Kuniaki Sato1, Farhoud Faraji2, Rodolfo Daniel Cervantes-Villagrana1

  • 1Moores Cancer Center, University of California San Diego, La Jolla, CA, USA; Department of Pharmacology, University of California San Diego, La Jolla, CA, USA.

Cancer letters
|January 18, 2025
PubMed
概括

小分子TEAD抑制剂通过破坏YAP/TAZ-TEAD相互作用,在HPV阴性头支状细胞癌 (HNSCC) 中表现出抗瘤活性. 这种方法针对HNSCC的一个关键漏洞,提供了潜在的新疗法.

关键词:
头癌是头部和部的癌症.河马的路径 河马的路径这是一种TEAD抑制剂.一个YAP1一个YAP1

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