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Updated: Jun 1, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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准线性激酶NEK2通过强化基因组不稳定性来增强CDK4/6抑制剂的有效性

Jessica R Bobbitt1, Leslie Cuellar-Vite2, Kristen L Weber-Bonk3

  • 1Department of Pathology School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.

The Journal of biological chemistry
|January 18, 2025
PubMed
概括

将循环素依赖的激酶4/6抑制剂 (CDK4/6i) 与NEK2抑制相结合,会诱导癌细胞中的染色体不稳定性 (CIN). 这种双重向有效地减少了瘤体积,并为乳腺癌治疗提供了新的治疗策略.

关键词:
这是一种CDK4/6抑制剂.在NEK2中,NEK2是NEK2.乳腺癌 乳腺癌 乳腺癌细胞循环中的细胞循环.细胞死亡是细胞死亡.组合疗法治疗组合治疗.基因组的不稳定性发生线粒分裂 (mitosis).线粒体灾难的灾难

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