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Updated: Jun 1, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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细胞周期CDK和cyclin对之间的结合亲和关系的差异

Sivasankar Putta1, Carina A Villegas1, Seth M Rubin1

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, United States.

Journal of molecular biology
|January 18, 2025
PubMed
概括

这项研究量化了细胞周期周期的环林依赖激酶 (CDK) 和环林相互作用,揭示了正规对表现出最高的亲和力. 这些发现为癌症中非正规对激活提供了洞察力.

关键词:
双层干涉测量是两层的干涉测量.细胞循环中的细胞循环.激酶激酶是一种激素.蛋白质蛋白质相互作用

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