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3D打印的类似水库的阴道环,用于输送抗生素

Arianna Chiappa¹, Alice Fusari¹, Marco Uboldi²

¹Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.

International journal of pharmaceutics

|January 18, 2025

概括

3D打印的阴道环 (VRs) 为细菌性阴道炎治疗提供可定制的长期释放的甲尼达. 这些新型药物输送系统通过避免频繁的药物管理来提高患者的服药性.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
药品制造药品制造药品制造

背景情况:

细菌性阴道炎 (BV) 治疗需要方便,持续的药物输送.
目前的甲尼达治疗涉及重复的管理,影响患者的遵守.
精准医学需要适应性药物输送系统,以提供个性化的治疗.

研究的目的:

开发和测试3D打印的类似水库的阴道环 (VRs),用于持续释放甲醇.
探索VR设计和水凝配方对药物释放动态的影响.
为定制的BV治疗建立一个多功能平台.

主要方法:

类似水库的VR原型是使用热塑性弹性体 (TPE) 3D打印制造的.
空洞的环形结构被填充了装载着美트로尼达 (MTZ) 的in-situ-crosslinking阿尔金酸盐 (ALG) 水凝.
研究了3个VR设计和9个含有不同MTZ度和ALG百分比的水凝配方.

主要成果:

在190°C成功3D打印TPE空心环结构.
虚拟现实释放性能取决于MTZ溶解度和阴道液接触的表面积.
药物释放与3D打印VRs的外部和内部结构相关.

结论:

3D打印的虚拟现实显示了可调节的,长时间的甲尼达输送的潜力.
开发的系统为个性化细菌性阴道炎治疗提供了一种多功能工具.
与传统的治疗方法相比,这种方法提高了方便性和合规性.

关键词:

基于酸盐的水凝.空洞的阴道环.甲尼达的使用方法个性化治疗是个性化的治疗.阴道感染阴道感染

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