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设计从纳米纤维贴片中持续释放的帕克利塔塞尔作为乳腺癌中潜在的局部纳米治疗药物

Razia Rehman¹, Muheeb Rafiq², Hasham Shafi³

¹Nanostructure and Biomimetic Lab, Department of Nanotechnology, University of Kashmir, Hazratbal, Srinagar 190006, Jammu and Kashmir, India; Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Jammu and Kashmir, India.

International journal of pharmaceutics

|January 18, 2025

概括

这项研究开发了帕克利塔塞尔 (PTX) 装载的聚乙烯 (PCL) 纳米纤维,用于持续治疗乳腺癌. 优化的纳米纤维贴片显示出有效的药物释放和对癌细胞的细胞毒性,表明局部治疗的潜力.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

乳腺癌是妇女死亡的主要原因之一.
帕克利塔塞尔 (PTX) 是乳腺癌的有效化疗剂.
需要局部和持续的药物输送系统来提高PTX的疗效和减少副作用.

研究的目的:

开发基于贴片的聚烯酸 (PCL) 纳米纤维,其中包含PTX,用于局部和持续的药物输送.
优化电旋转参数,使用质量设计方法来增强药物输送.
评估开发的纳米纤维系统的物理化学特性,药物释放动力学和体外细胞毒性.

主要方法:

PCL和聚乙烯醇 (PVA) 的电,以制造含有药物的纳米纤维.
参数优化的质量通过设计方法.
使用FE-SEM,XRD,FT-IR,TGA和DSC进行物理化学表征.
在体外药物释放研究和MTT细胞毒性测定.

主要成果:

优化的纳米纤维配方 (Fo) 实现了92.7%的产量,具有统一的,无珠形态.
平均纤维直径为547纳米,药物捕获率为85%.
在纳米纤维矩阵内观察到PTX无形化,与聚合物没有化学相互作用.
持续PTX释放长达17天,对MDA-MB-231乳腺癌细胞具有显著的细胞毒性.

结论:

开发的带有PTX的PCL/PVA纳米纤维子代表了乳腺癌治疗的有前途的局部药物输送系统.
优化的配方确保了持续的药物释放和有效的细胞毒性.
需要进一步的体外研究来验证治疗潜力.

关键词:

盒子-Behnken设计的设计.乳腺癌乳腺癌乳腺癌装有药物的纳米纤维.持续的药物输送是持续的药物输送

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